Primary Care in Cape Girardeau, Missouri
Guardian Primary Care is at 2441 Myra Dr, caring for families across Cape Girardeau and Southeast Missouri. Empowered in care, excellence in health.
Visit Us
- Address
- Guardian Primary Care
2441 Myra Dr
Cape Girardeau, MO 63703 - Phone
- (573) 200-6143
- Fax
- (573) 755-0706
- Hours
- By appointmentClosed on US major holidays
Serving Cape Girardeau and Southeast Missouri
Guardian Primary Care has cared for patients in Cape Girardeau since 2024. Families come to us from across the region, including Jackson, Scott City, Perryville, Sikeston, and Chaffee, because quality care close to home should not require a long drive or a long wait.
Patients choose Guardian for the way visits feel: unhurried, honest, and focused on finding the root cause rather than moving you along. Preston Holifield, DNP, APRN, FNP-C leads care here, working with a Missouri Licensed Collaborating Physician and referring you to a specialist whenever that is the right next step. Our goal is a clinic where you can speak freely and leave knowing what happens next.
For patients with busy schedules or a long drive, we also offer telehealth appointments, so follow-ups and many routine concerns can be handled without coming in.
Care Available at Our Cape Girardeau Office
Family Primary Care
Wellness visits, sick visits, and ongoing care for the whole family, from newborns through seniors.
Learn More →
Wellness & Prevention
Annual wellness exams, cancer screenings, nutrition counseling, and the labs that catch problems early.
Learn More →
Guardian Direct Care
Our membership alternative to insurance billing: transparent pricing and direct access to your provider.
Learn More →A Long Drive? Ask About Telehealth
If you are coming from Perryville, Sikeston, or anywhere else that turns a short visit into a long afternoon, a telehealth appointment may be all you need. Virtual visits work well for follow-ups, medication management, results reviews, and many routine concerns.
You see the same provider, and the visit goes in the same chart as your in-person care. When a concern needs an exam, labs, or a procedure, we will tell you and get you scheduled at the office.
Frequently Asked Questions
Where is Guardian Primary Care located?
Our office is at 2441 Myra Dr, Cape Girardeau, MO 63703. You can open the address in Google Maps for turn-by-turn directions from wherever you are starting. If you would rather have directions over the phone, call us at (573) 200-6143.
Which communities do you serve?
We care for patients in Cape Girardeau and throughout Southeast Missouri, including Jackson, Scott City, Perryville, Sikeston, and Chaffee. If the drive is long or your week is tight, a telehealth visit may be a good option for follow-ups and many routine concerns.
What are your office hours?
Guardian Primary Care sees patients by appointment, and the office is closed on US major holidays. Call (573) 200-6143 and we will find a time that works for you.
Do you take my insurance?
We are in-network with most major commercial insurances, Medicare and Medicaid, so most patients can use the coverage they already have. If you would rather not deal with insurance billing, Guardian Direct Care is our membership option, with predictable pricing and no surprise bills. Call the office to confirm your specific plan.
Do you offer telehealth?
Yes. Guardian Primary Care offers both in-person and telehealth appointments. Virtual visits work well for follow-ups, medication management, and many routine concerns. If your provider decides your concern needs an exam or labs, we will bring you in. Learn more about telehealth.
How do I become a new patient?
New patients can schedule a first appointment online or call us at (573) 200-6143. Patients already established with us can self-schedule through the Patient Ally portal. Let us know when you book if you have any accessibility or scheduling needs, and we will plan around them.
Care That Is Close to Home
Visit us at 2441 Myra Dr in Cape Girardeau, or connect by telehealth. Guardian Primary Care sees patients by appointment, so call or request a time online.