We Are In-Network With Most Major Commercial Insurances, Medicare, & Medicaid

Full List of In-Network Insurances

Prefer Direct-Care? No Problem.

Guardian Direct Care

Care Built Around Access, Trust, and Thoughtful Care

Care & Access

A Peek Inside Our Practice

Stronger Care for Aging Adults, Together

We’re honored to serve the mission of our community partners dedicated to improving the lives of older adults and caregivers affected by dementia & pertinent comorbidities. Their commitment to compassionate support, clear communication, and evidence-based care helps us bring stability and dignity to patients and families in our community. Experience Excellent, Empowering Care.

Access Dementia Care Access Care Giver Support

Your Premier Wellness & Prevention Specialists

Learn about preventative steps you can take to optimize your health to live a long, happy life as the best version of yourself

Nutrition Counseling Cancer Screenings Mental Health School, Sports, & Employment Screenings Exercise & Activity Women's Wellness Routine Annual Wellness Wellness Care & Counseling

Licensed, Experienced, & Trusted Primary Care Experts

Take a Peek at a List of a Few of Our National, State, & Local Certifying & Licensing Bodies Below. We Believe Our Patient Deserve the Highest Standards of Healthcare Excellence.

A Proud of Supporter of PrestonNP

PrestonNP is a health education platform created by Preston Holifield, DNP, APRN, FNP-C, designed to make health education understandable, engaging, and empowering for everyday people.

Watch Now

We offer compassionate care for every stage of life, from childhood to retirement.

Family Primary Care

Guardian offers an aesthetics line with licensed Botox injectors here to help you achieve the happiest, healthiest, best version of yourself.

Explore Botox

Meet the Provider team at Guardian — dedicated to building lasting relationships through thoughtful, evidence-based care.

Meet Your Providers

Our licensed Provider team offer expert guidance & flexible treatment options for weight loss.

Explore Weight Loss

We accept most insurance plans, HSA/FSA, and flexible self-pay options to fit your needs.

Accepted Payment Methods

We proudly collaborate with trusted specialists and local partners to support comprehensive care.

Referrals & Affiliates

Patient Testimonials

"I have nothing but positive things to say about Preston and GPC! From working with him on shared patients to trusting him with the care of my family members, he is thorough and very competent. I love that he takes his time with each patient and looks for real solutions instead of pushing medicine. I highly recommend him!

- Laura M. Sanders

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"Guardian Primary Care is a fantastic addition to Cape Girardeau! The staff is professional, friendly, and truly cares about their patients. The clinic has a welcoming atmosphere, and the option for both in-person and tele-health appointments makes scheduling so convenient. It’s refreshing to see a healthcare provider that puts such an emphasis on patient comfort and accessibility. Highly recommend for anyone looking for reliable and compassionate primary care!"

- Sho R.

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"Preston is very thorough with his patients. He answers any and all questions that one may have. Highly recommend to anyone looking for a PCP that is easy to get in with and doesn’t break the bank!"

- Mercedes Stiltner

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"I felt very respected and valued here as a patient."

- Brea Baker

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"I’m incredibly grateful for the care of Preston Holifield! He goes above and beyond as a patient advocate, always putting his people first. He serves with kindness and excellence, ensuring every patient receives the best care possible. Despite my tight schedule, he found a way to fit me in, addressed all my needs, and even followed up to make sure everything was going as it should. I highly recommend him—he’s the Chick-fil-A of primary care!"

- Jessica S.

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"Love the practice. Extremely friendly and professional. Really takes the time to listen to their patients and very easy to work with when finding new solutions."

- Jared Mungle

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"Guardian has been a pleasant experience. Preston is very personable and professional. He actually listens and cares about your needs and doesn't feel like he trying to push you through like some places"

- Jeremy Franklin

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"We Would Love to Hear From You! Share Your Testimonial by Submitting the Contact Form with Your Review Found at the Link Below!"

- Guardian Primary Care Team

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Primary Care for All Ages

Empower Your Care, Achieve Excellence in Your Health.

We Are In-Network With Most Major Commercial Insurances, Medicare, & Medicaid

Prefer Direct-Care? No Problem.

Guardian Direct Care

A Peek Inside Our Practice

Stronger Care for Aging Adults, Together

Your Premier Wellness & Prevention Specialists

Licensed, Experienced, & Trusted Primary Care Experts

A Proud of Supporter of PrestonNP

Patient Testimonials

Leave us a Review

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Established 2024