Primary Care for Your Whole Family
Personalized care in Cape Girardeau for every stage of life.
Quality primary care in Cape Girardeau. Most major insurance plans, Medicare and Medicaid accepted. Or choose simple monthly pricing with Guardian Direct Care.
Explore Affordable Care OptionsMeet Guardian Primary Care
A provider owned and operated practice in Cape Girardeau, Missouri.
How We Can Help
Comprehensive care tailored to you and your family's needs at every stage of life, right here in Cape Girardeau.
Family Primary Care
Care for every member of the family, from childhood through retirement. Routine check-ups, sick visits, chronic condition management and preventative care, in person or by telehealth.
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Dementia & Aging Adult Care
Support for older adults and the families caring for them, including memory concerns, medication review, care coordination and caregiver guidance, with dignity at the center of every visit.
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Wellness & Prevention
Annual wellness visits, cancer screenings, nutrition counseling, exercise and activity guidance, and school, sports and employment screenings to keep small things from becoming big ones.
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Meet Your Provider
Preston Holifield, DNP, APRN, FNP-C
Primary Care Provider, Guardian Primary Care
Preston believes in evidence-based, guideline-directed healthcare. Through joint efforts with his Missouri Licensed Collaborating Physician, Preston employs his years of nursing experience to delve into the root cause of his patients' health concerns. He believes in caring, and going above and beyond for each and every one of his patients.
Preston believes all his patients at Guardian should feel the clinic is a safe place to speak freely and experience healing of the mind, body and spirit, in order to become the happiest, healthiest, best versions of themselves. He is a Nationally Certified Family Nurse Practitioner through the American Academy of Nurse Practitioners, licensed by the Missouri State Board of Nursing, and earned his Doctorate of Nursing Practice at Arkansas State University after completing his MSN and BSN at Southeast Missouri State University.
Meet the Guardian Team →Find the Right Care for You
See your primary care options in Cape Girardeau.
Coverage and what you pay depend on your plan and the care you receive, and are confirmed with you before your visit. Guardian Direct Care prices are the practice's published membership rates.
What Our Patients Say
In our patients' own words.
I have nothing but positive things to say about Preston and GPC! From working with him on shared patients to trusting him with the care of my family members, he is thorough and very competent. I love that he takes his time with each patient and looks for real solutions instead of pushing medicine. I highly recommend him!
Guardian Primary Care is a fantastic addition to Cape Girardeau! The staff is professional, friendly, and truly cares about their patients. The clinic has a welcoming atmosphere, and the option for both in-person and tele-health appointments makes scheduling so convenient. It's refreshing to see a healthcare provider that puts such an emphasis on patient comfort and accessibility. Highly recommend for anyone looking for reliable and compassionate primary care!
Preston is very thorough with his patients. He answers any and all questions that one may have. Highly recommend to anyone looking for a PCP that is easy to get in with and doesn't break the bank!
Getting Started Is Simple
Schedule Your Visit
New patients can request a first appointment online or call us at (573) 200-6143. Already a patient? Self-schedule on the Patient Ally portal. Visits are by appointment, in person or by telehealth.
Meet Your Provider
Your provider takes the time to understand your health history, your current concerns and your goals. We believe in collaborative care, where you are an active partner in every decision about your health.
Receive Ongoing Care
Healthcare does not end when you leave our office. We provide continuing support through follow-up visits, care coordination and referrals when a specialist is the right next step, so nothing falls through the cracks.
Access, Trust, and Thoughtful Care for Life
Guardian Primary Care serves Cape Girardeau and the surrounding Southeast Missouri communities, including Jackson, Scott City and Perryville. Our vision is to become the premier healthcare provider in Southeast Missouri.
2441 Myra Dr, Cape Girardeau, MO 63703 · By Appointment · Closed on US major holidays